Table 4.

Risk of cancer in 10-year intervals for MSH6 mutation carriers at ages 50, 60, and 70 years who have had no previous diagnosis of the cancer (or group of cancers) at the beginning of the 10-year period^*

		10-y cancer risk at age, % (95% CI)
Cancer	Sex	50 y	60 y	70 y
Colorectal cancer	Male	6 (3 to 9)	14 (8 to 22)	28 (16 to 45)
	Female	3 (1 to 5)	6 (3 to 11)	11 (4 to 23)
Endometrial	Female	7 (5 to 11)	14 (9 to 21)	24 (14 to 36)
Any Lynch cancer†	Male	6 (4 to 10)	15 (9 to 24)	31 (17 to 48)
	Female	12 (9 to 17)	24 (17 to 33)	41 (29 to 55)

^*For example, a man with no previous colorectal cancer diagnosis at age 70 years has a 28% risk for development of a colorectal cancer by age 80 years.

^†Any Lynch cancers include cancers of the colorectum, endometrium, kidney, stomach, ovary, small bowel, ureter, and brain.