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. 2009 Nov 19;1(11):937–948. doi: 10.18632/aging.100103

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Copyright: ©2009 Krishnan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Oxidative damage accumulates to higher levels in aging per⁰¹flies. Fold increase was calculated based on day 5 values in CS^p males under normoxia (numerical values are shown in Supplementary Table 2 and Supplementary Table 3). Top: Protein carbonyls (PC) in heads (A) and bodies (B) of CS^p (solid line) and per⁰¹(broken line) in normoxia (black) and after hyperoxia (gray). PC levels were significantly higher in per⁰¹than in CS^pfly heads on day 35 and 50, and on day 50 in bodies under normoxia. Hyperoxia on day 35 and 50 induced significantly higher PC levels per⁰¹head and bodies compared to CS^p age-matched controls. Bottom: Lipid peroxidation product 4-HNE in heads (C) and bodies (D). In normoxia, per⁰¹flies accumulated significantly more 4-HNE in heads and bodies compared to CS^p in all ages except day 5. Under hyperoxia, significant increase in 4-HNE accumulation was observed in per⁰¹heads and bodies on day 20, 35 and 50 compared to CS^p males. For statistical analysis of PC and HNE data refer to Supplementary Table 2 and Supplementary Table 3.