Table 4. Genetic associations in combined MoBa and Cenn samples.
Sample | Gene | SNP | Allele | Cenn Case Allele Freq | Cenn Cont Allele Freq | Cenn Allele p | Cenn Genotype p | MoBa Case Allele Freq | MoBa Cont Allele Freq | MoBa Allele p | MoBa Genotype p | Pooled Case Allele Freq | Pooled Cont Allele Freq | Pooled Allele p | Pooled Genotype p |
Maternal | PTGER3 | rs977214 | G | 0.09 | 0.13 | 0.17 | 5×10−3 | 0.06 | 0.09 | 0.06 | 0.04 | 0.071 | 0.112 | 0.02* | 3×10−4 ** |
rs6665776 | A | 0.09 | 0.12 | 0.24 | 0.01 | 0.06 | 0.09 | 0.06 | 0.04 | 0.071 | 0.11 | 0.02* | 5×10−4 * | ||
rs2072947 | C | 0.53 | 0.44 | 0.02 | 0.03 | 0.41 | 0.46 | 0.21 | 0.03 | 0.46 | 0.45 | 0.58* | 0.04* | ||
Fetal | PON1 | rs854552 | C | 0.22 | 0.28 | 0.12 | 0.25 | 0.21 | 0.30 | 2×10−3 | 6×10−3 | 0.21 | 0.29 | 8×10−4 * | 2×10−3 * |
rs2272365 | G | 0.19 | 0.13 | 0.05 | 0.05 | 0.17 | 0.12 | 0.04 | 0.12 | 0.18 | 0.13 | 5×10−3 * | 0.01* |
cases deviated from HWE at rs977214 (p = 0.02), rs6665776 (p = 0.02).
controls deviated from HWE at rs977214 (p = 0.05).
*Significant after correction for multiple testing with FDR (q = 0.2).
**Significant after correction for multiple testing with Bonferroni.