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Ribonuclease Protection Assay (RPA) demonstrating the presence of both the wild-type and the EGFRvIII transcript. A813 is a 4th passage of xenograft with an amplified and rearranged EGFR gene, which mainly express the EGFRvIII transcript. GB182 is a GB without amplification of the EGFR gene but that express the EGFRvIII transcript, as is demonstrated here. GB180 and AA108 are tumours with EGFR amplification that only express the wild-type transcript.
