TABLE 1.
Linkage mapping of the domestic cat Tabby locus
| Markera | Cat chr. | GL map positionb | RH map positionb | Peak LODc | Θ of peakc | Position in GARFIELD (start)d | Hsa36 (start)e | Cfa2 (start)e |
|---|---|---|---|---|---|---|---|---|
| FCA566 | A1 | 144.8 | 755.7 | 31.36* | 0.01* | Chr Un8: 85,018 | Unknown | Unknown |
| FLT4 | A1 | — | — | 28.73 | 0.03 | Chr Un11: 349,316 | Chr 5: 179,972,586 | Chr 11: 4,173,747 |
| ChrUn11_369202 | 24.99 | 0.05 | Chr Un11: 369,202 | Chr 5: 179,954,132 | Chr 11: 4,190,117 | |||
| Hsa5:179.47 | A1 | — | — | 23.43* | 0.02* | Chr Un11: 699,876 | Chr 5: 179,470,809 | Chr 11: 4,568,828 |
| Hsa5:178.67 | A1 | — | — | 20.19 | 0.02 | Chr Un11: 1,234,398 | Chr 5: 178,672,817 | Chr 11: 5,312,931 |
| Col23A1 | A1 | — | — | 21.32 | 0.06 | Chr A1: 124,220,448 | Chr 5: 177,617,085 | Chr 11: 6,306,204 |
| YTHDC2 | A1 | — | — | 37.78 | 0.01 | Chr A1: 123,872,511 | Chr 5: 112,958,230 | Chr 11: 6,617,669 |
| Cfa11:7.68 | A1 | — | — | 30.27 | 0 | Chr A1: 123,080,103 | Chr 5: 113,730,035 | Chr 11: 7,288,271 |
| FCA1331 | A1 | 147.3 | — | 42.61 | 0 | Chr A1: 122,968,298 | Chr 5: 113,814,901 | Chr 11: 7,382,372 |
| Hsa 5-116.83 | A1 | — | — | 32.45 | 0 | Chr Un11: 2,154,347 | Chr 5: 116,836,837 | Chr 11: 10,069,791 |
| Hsa-5-118.59 | A1 | — | — | 40.85 | 0.01 | Chr Un11: 3,108,430 | Chr 5: 118,596,950 | Chr 11: 11,556,021 |
| Hsa5-118.72 | A1 | — | — | 34.57 | 0.01 | Chr Un11: 3,208,206 | Chr 5: 118,721,887 | Chr 11: 11,656,633 |
| Cfa11:11.26 | A1 | — | — | 22.92* | 0.01* | Chr Un11:253,059 | Chr 5: 119,149,336 | Chr 11: 13,698,383 |
| Cfa11:12.55 | A1 | — | — | 30.58* | 0.01* | Chr Un11: 4,235,006 | Chr 5: 120,543,823 | Chr 11: 14,227,481 |
| FCA90 |
A1 |
154.7 |
947.3 |
10.67* |
0.05* |
Unknown |
Chr 5: 123,155,913 |
Chr 11: 16,596,908 |
Markers are shown in genomic order along the domestic cat chromosome A1, on the basis of the most recent genetic linkage (GL) (Menotti-Raymond et al. 2009) and radiation hybrid (RH) (Davis et al. 2009) maps of the domestic cat. Markers with prefix other than FCA represent loci that were developed for fine mapping after multipoint linkage analysis demonstrated that FCA566 and FCA90 flanked the Tabby interval.
Positions of markers with a blank in these columns were not determined in those versions of the RH or GL maps.
Peak LOD score and estimated recombination fraction (θ) for linkage between each polymorphic marker and the Tabby locus. Asterisks indicate loci that were genotyped only in the Nestlé-Purina colony (pedigree 1); all other loci were additionally genotyped in pedigree 2 and reflect cumulative LOD scores from the two pedigrees.
Position in the domestic cat whole genome sequence assembly as visualized in the GARFIELD browser (Pontius and O'Brien 2007) (http://lgd.abcc.ncifcrf.gov/cgi-bin/gbrowse/cat).
Columns 8 and 9 show the positions in the human (HSA build 36) (http://www.ncbi.nlm.nih.gov/projects/mapview/stats/BuildStats.cgi?taxid=9606&build=36&ver=3) and dog (CFA build 2) (http://www.ncbi.nlm.nih.gov/projects/mapview/stats/BuildStats.cgi?taxid=9615&build=2&ver=1) genome assemblies found by BLAT analysis to be orthologous to sequences flanking the respective domestic cat markers.