TABLE 2.
Linkage mapping of the domestic cat Ticked locus
| Markera | Cat chr. | GL map positionb | RH map positionb | Peak LODc | Θ of peakc | Position in GARFIELD (start)d | Hsa36 (start)e | Cfa2 (start)e |
|---|---|---|---|---|---|---|---|---|
| FCA522 | B1 | 47.9 | 197.8 | 11.39 | 0.09 | B1: 20,954,176 | Chr 8: 12,886,556 | Chr 16: 39,395,506 |
| FCA519 | B1 | 60.2 | 247.2 | 11.60 | 0.05 | B1: 26,480,800 | Chr 8: 32,537,942 | Chr 16: 34,857,499 |
| ChrB1_36137001 | B1 | 14.36 | 0.05 | B1: 36,137,001 | Chr 8: 25,348,288 | Chr 25: 35,009,943 | ||
| ChrB1_38697912 | B1 | 7.53 | 0.03 | B1: 38,697,912 | Chr 8: 23,191,720 | Chr 25: 37,192,502 | ||
| ChrB1_38976563 | B1 | 20.32 | 0 | B1: 38,976,563 | Chr 8: 22,766,523 | Chr 25: 37,435,625 | ||
| ChrB1_39401113 | B1 | 19.41 | 0 | B1: 39,401,113 | Chr 8: 22,400,723 | Chr 25: 37,774,501 | ||
| ChrB1_39665480 | B1 | 12.34 | 0 | B1: 39,665,480 | Chr 8: 22,151,140 | Chr 25: 38,010,313 | ||
| ChrB1_39873803 | B1 | 18.52 | 0 | B1: 39,873,803 | Chr 8: 21,963,551 | Chr 25: 38,177,122 | ||
| ChrB1_40183201 | B1 | 11.53 | 0 | B1: 40,183,201 | Chr 8: 21,646,142 | Chr 25: 38,463,167 | ||
| ChrB1_41254204 | B1 | 16.10 | 0 | B1: 41,254,204 | Chr 8: 20,606,466 | Chr 25: 39,390,344 | ||
| ChrB1_41701042 | B1 | 16.40 | 0 | B1: 41,701,042 | Chr 8: 20,198,053 | Chr 25: 39,762,212 | ||
| ChrB1_41772882 | B1 | 17.89 | 0 | B1: 41,772,882 | Chr 8: 20,127,674 | Chr 25: 39,821,805 | ||
| ChrB1_41799674 | B1 | 10.02 | 0 | B1: 41,799,674 | Chr 8: 20,104,102 | Chr 25: 39,846,768 | ||
| ChrB1_41829103 | B1 | 17.00 | 0 | B1: 41,829,103 | Chr 8: 20,085,589 | Chr 25: 39,870,873 | ||
| ChrB1_42060627 | B1 | 2.86 | 0 | B1: 42,060,627 | Chr 8: 19,843,732 | Chr 25: 40,092,520 | ||
| FCA559 | B1 | 381.0 | 17.33 | 0 | unknown | Chr 8: 19,546,837 | Chr 16: 25,388,799 | |
| ChrB1_53277193 | B1 | 18.77 | 0 | B1: 53,277,193 | Chr 8: 19,709,004 | Chr 16: 25,555,047 | ||
| ChrB1_53355916 | B1 | 13.86 | 0 | B1: 53,355,916 | Chr 8: 43,120,843 | Chr 16: 25,623,485 | ||
| ChrB1_53581031 | B1 | 14.81 | 0.02 | B1: 53,581,031 | Chr 8: 42,881,429 | Chr 16: 25,839,630 | ||
| CFA16:29.97 | B1 | 14.09 | 0.03 | unknown | Chr 8: 38,458,010 | Chr 16: 29,972,613 | ||
| FCA23 | B1 | 83.6 | 463.3 | 11.90 | 0.05 | Un: 77,729,549 | Chr 8: 31,307,618 | Chr 16: 32,706,503 |
| FCA809 | B1 | 84.5 | 476.7 | 12.43 | 0.05 | B1: 68,657,050 | Chr 8: 27,646,753 | Chr 25: 32,866,052 |
| FCA811 | B1 | 84.5 | 488.6 | 1.15 | 0.10 | B1: 68,391,021 | Chr 8: 27,433,306 | Chr 25: 33,063,420 |
| FCA700 |
B1 |
108.1 |
571.9 |
7.24 |
0.10 |
B1: 74,811,696 |
Chr 8: 174,967,845 |
Chr 25: 27,356,441 |
Markers are shown in genomic order along the domestic cat chromosome B1, on the basis of the most recent genetic linkage (GL) (Menotti-Raymond et al. 2009) and radiation hybrid (RH) (Davis et al. 2009) maps. Markers with prefix “chrB1” represent loci that were developed for fine mapping after multipoint linkage analysis demonstrated that FCA23 and FCA519 flanked the Ticked interval.
Positions of markers with a blank in these columns were not determined in those versions of the RH or GL maps.
Peak LOD score and estimated recombination fraction (θ) for linkage between each polymorphic marker and the Ticked locus.
Position in the domestic cat whole genome sequence assembly as visualized in the GARFIELD browser (Pontius and O'Brien 2007). “Un” refers to a sequence block unassigned to a chromosome.
Columns 8 and 9 show the positions in the human (HSA build 36) (http://www.ncbi.nlm.nih.gov/projects/mapview/stats/BuildStats.cgi?taxid=9606&build=36&ver=3) and dog (CFA build 2) (http://www.ncbi.nlm.nih.gov/projects/mapview/stats/BuildStats.cgi?taxid=9615&build=2&ver=1) genome assemblies found by BLAT analysis to be orthologous to sequences flanking the respective domestic cat markers.