Table 4.
Univariate and Multivariate Logistic Regression Analysis of Risk of Reinduction Failure
| Variable | No. | Univariate Analyses |
Multivariate Analyses |
||
|---|---|---|---|---|---|
| OR* | 95% CI* | OR† | 95% CI† | ||
| Treatment attempt | |||||
| Second | 191 | 1.0 | — | 1.0 | — |
| Third | 108 | 7.3 | 4.2 to 12.6 | 4.5 | 2.4 to 8.4 |
| Fourth | 56 | 15.9 | 7.8 to 32.5 | 5.8 | 2.4 to 14.1 |
| Fifth through ninth | 65 | 41.5 | 17.9 to 96.2 | 14.3 | 4.9 to 41.5 |
| P | < .001 | < .001 | |||
| P trend‡ | < .001 | < .001 | |||
| Duration of previous remission | |||||
| CR not achieved | 105 | 4.1 | 2.3 to 7.2 | 2.3 | 1.02 to 5.0 |
| CR achieved, < 18 months duration | 147 | 1.0 | — | 1.0 | — |
| CR achieved, 18 to 36 months duration | 82 | 0.31 | 0.17 to 0.56 | 0.52 | 0.27 to 1.03 |
| CR achieved, ≥ 36 months duration | 67 | 0.082 | 0.031 to 0.21 | 0.20 | 0.07, to 0.55 |
| Missing | 19 | ||||
| P | < .001 | < .001 | |||
| P trend‡ | < .001 | < .001 | |||
| NCI risk criteria at diagnosis | |||||
| Non-infants, standard risk | 176 | 1.0 | — | 1.0 | — |
| Non-infants, high risk | 180 | 1.5 | 0.98 to 2.3 | 1.4 | 0.82 to 2.5 |
| Non-infants, unknown | 53 | 2.0 | 1.1 to 3.7 | 0.74 | 0.32 to 1.7 |
| Infants | 11 | 0.93 | 0.26 to 3.3 | 2.1 | 0.47 to 9.8 |
| P | .011 | .31 | |||
| Extramedullary involvement in relapse | |||||
| No | 331 | 1.0 | — | 1.0 | — |
| Yes | 82 | 0.53 | 0.32 to 0.88 | 0.68 | 0.36 to 1.3 |
| Missing | 7 | ||||
| P | .011 | .23 | |||
| Immunophenotype | |||||
| Pre B cell | 348 | 1.0 | — | 1.0 | — |
| T cell | 72 | 2.0 | 1.2 to 3.3 | 1.2 | 0.60 to 2.4 |
| P | .012 | .61 | |||
Abbreviations: OR, odds ratio of achieving complete remission v < complete remission; CR, complete remission; NCI, National Cancer Institute.
*
ORs and 95% CIs from univariate logistic models.
†
ORs and 95% CIs from multivariate logistic models after adjusting for the other variables in the Table.
‡
Test for trend.