Table 1.

Diagnostic Criteria of Smoldering Multiple Myeloma in the Different Reported Series

Study	M Protein (g/dL)	Bone Marrow Plasma Cells (%)
Kyle and Greipp, 19801	≥ 3	≥ 10
Alexanian et al 19883	> 2	—
Wisloff et al 19914	IgA > 1.5; IgG > 3	—
Facon et al 19956	—	> 15
Weber et al 19977	> 2.5	—
Cesana et al 20028*	IgA 2.1-4.9; IgG 3.6-6.9; light chain proteinuria > 1 g/24 h	> 10
Rosiñol et al 20039†	≥ 3	≥ 10
IMWG 200310‡	≥ 3	≥ 10

Abbreviations: Ig, immunoglobulin; IMWG, International Myeloma Working Group.

^*Either diagnostic criterion is acceptable.

^†Both diagnostic criteria are required.

^‡Either or both diagnostic criteria are acceptable.