Table 3.

Factors Asociated With Progression to Symptomatic MM and Risk Groups

Study by	Risk Factors	Risk Group by Factors
		Low	Intermediate	High
Alexanian et al, 19883	Lytic bone lesions; M protein > 30 g/L	0	—	1-2
Wisloff et al, 19914	Lytic bone lesions; BMPC > 20%	0	—	1-2
Dimopoulos et al, 19935	Lytic bone lesions; M protein > 30 g/L; proteinuria > 50 mg/24 h	No lysis, +0	No lysis, +1	Lysis, +2
Facon et al, 19956	Hb < 12 g/L; BMPC > 20%; M protein > 30 g/L (IgG); M protein > 25 g/L (IgA)	0	1	2-3
Weber et al, 19977	M protein > 30 g/L; IgA M-protein type; proteinuria > 50 mg/24 h	0	1	2-3
Cesana et al, 20028	BMPC > 10%; IgA M-protein type; proteinuria	0	—	1-3

Abbreviations: MM, multiple myeloma; BMPC, bone marrow plasma cells; Hb, hemoglobin; Ig, immunoglobin.