Table 5.

Recommended Work Up at Baseline in Patients With Suspected Smoldering Multiple Myeloma

Medical history and physical examination

CBC

Serum calcium and creatinine

Protein studies

Total serum protein and serum electrophoresis (serum M-protein quantitation)

24-h urine protein electrophoresis (urine M-protein quantitation)

Serum and urine immunofixation

Serum free light chain measurement (FLC ratio)

β2-microglobulin

Bone marrow aspirate

Skeletal survey

MRI of thoracic-lumbar spine and pelvis

Abbreviations: FLC, free light chain; MRI, magnetic resonance imaging.