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. 2009 Aug 3;8(12):2796–2808. doi: 10.1074/mcp.M900285-MCP200

Fig. 6.

Fig. 6.

Effect of dasatinib on the BCR-ABL signaling pathway. Phosphorylation sites that were suppressed by both 5 and 50 nm dasatinib are displayed on the left. Signaling pathways are based on Weisberg et al. (60). FAK, focal adhesion kinase; DOK, docking protein 1; RSK, 90-kDa ribosomal protein S6 kinase; CRKL, Crk-like protein; CAS, Crk-associated substrate; SPAG, sperm-associated antigen; SOS, Son of sevenless; VAV, Vav proto-oncogene; SHIP, SH2 domain-containing inositol phosphatase; CRK, Crk proto-oncogene; CBL, Cbl protein, Cas-Br-M (murine) ecotropic retroviral transforming sequence; SHC, SHC-transforming protein.