Table II. Marker phosphopeptides down-regulated by dasatinib.
Underscores denote the beginning and the end of the peptide sequence in the protein sequence. pY, phosphotyrosine; pS, phosphoserine; pT, phosphothreonine.
| Name | Phospho position | No. phosphosites | Sequence | M/L | H/L |
|---|---|---|---|---|---|
| BCR | 122 | 1: Ser | _ASASRPQPAPADGADPPPAEEPEARPDGEGpSPGK_ | 0.3 | 0.2 |
| 644 | 1: Tyr | _NSLETLLpYKPVDR_ | 0.3 | 0.1 | |
| ABL1 | 805, 808 | 2: Ser, Ser | _DIMEpSpSPGSSPPNLTPK_ | 0.4 | 0.4 |
| 248 | 1: Ser | _NKPTVYGVpSPNYDK_ | 0.6 | 0.4 | |
| 245 | 1: Tyra | _NKPTVpYGVSPNYDK_ | 0.4 | 0.4 | |
| SRC | 426 | 1: Tyra | _LIEDNEpYTAR_ | 0.4 | 0.1 |
| MAPK1 | 185, 187 | 2: Thr, Tyra | _VADPDHDHTGFLpTEpYVATR_ | 0.1 | 0.1 |
| MAPK3 | 202, 204 | 2: Thr, Tyra | _IADPEHDHTGFLpTEpYVATR_ | 0.1 | 0.1 |
| MYC | 62 | 1: Ser | _KFELLPTPPLpSPSR_ | 0.4 | 0.2 |
| LYN | 578 | 1: Tyr | _AEERPTFDYLQSVLDDFYTATEGQpYQQQP_ | 0.3 | 0.3 |
a Autophosphorylation sites.