Table 3. Over representation of conserved transcription factor binding sites within putatively co-regulated genes.
GO term and Gene Symbol* | Transcription Factors | Probability** |
Metabolism | ||
SQLE, EBP, TIMP1, DHRS4, UBE2J1, | FOXJ2 | 3.31E-156 |
UBE2NL, PAH, HSP90B1, GCDH | FOXD3 | 5.75E-136 |
DHFR, FADS, SIRT6, AKR1B1 | HFH-3 | 2.42E-128 |
C4B, SLC25A5 | IRF-1 | 4.06E-108 |
SREBP-1 | 1.41E-53 | |
E47 | 1.17E-52 | |
MEF-2 | 6.67E-42 | |
AREB6 | 9.87E-41 | |
ARP-1 | 1.51E-35 | |
Signal Transduction | ||
TBL1X, RYK, DDX54, TNFRSF14, | FOXJ2 | 3.04E-58 |
KISSIR, FCER1G, NFkB2 | FOXD3 | 5.50E-58 |
IRF-1 | 3.42E-52 | |
HFH-3 | 8.90E-48 | |
SREBP-1 | 2.71E-19 | |
CHOP:C/EBPalpha | 2.51E-14 | |
ARP-1 | 1.26E-13 | |
Freac-7 | 2.98E-12 | |
E47 | 2.78E-11 | |
MEF-2 | 5.14E-11 | |
Regulation of biological processess | ||
CASZ1, PUM1, C4B, GTF2H3 | MEF-2 | 1.06E-14 |
ATF5, | CHOP:C/EBPalpha | 1.93E-14 |
FOXJ2 | 6.57E-13 | |
AREB6 | 3.25E-12 | |
SREBP-1 | 3.96E-12 | |
ARP-1 | 1.69E-11 | |
p300 | 2.32E-11 | |
FOXD3 | 3.39E-11 | |
SREBP-1 | 3.09E-10 | |
NF-E2 | 3.89E-10 |
*Genes that clustered together and occurred within the same GO term.
**Significant probability of the binding of the respective transcription factors to the indicated sets of genes.