Table 1. Cellular processes that can be targeted by PknB.
Transport Total: 5 proteins | Cell growth and maintanance Total: 10 proteins |
membrane transport proteins, voltage gated channel, water channel proteins | structural proteins, cell cycle regulation proteins, cell adhesion proteins |
Metabolism Total: 2 proteins | Immune response and recognition Total: 3 proteins |
phosphotransferase, ribosomal subunit | immunoglobulin, cell surface receptors |
Signal transduction and Cell communication Total: 32 proteins | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism Total: 13 proteins |
receptors, cell cycle proteins, cell junction proteins, serine/threonine kinases, tyrosine kinases, transport/cargo proteins, adapter molecules | DNA binding site, RNA binding site, ribonucleoproteins, transcription factors, transcription regulatory proteins |
Apoptosis Total: 1 protein | Stress Total: 2 proteins |
Bcl2- interacting protein BIM | Heat-shock proteins |
Functional classes of human proteins that are potentially phosphorylated by PknB, as identified in the present PepChip analysis, are classified by their biological function.