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Effect of increasing Hsp90 ATPase activity on Raf-1P and Cyclin D1 levels. Raf-1, a major Hsp90 client protein, is an oncogene and when over-activated, results in tumor cell proliferation by the AP-1 mediated expression of Cyclin D1. An increase in Hsp90 ATPase activity results in an increased level of Raf-1P and Cyclin D1
