Fig. 3.

(A) Expression of VEGF according to the time after irradiation. Whereas the level of expression of VEGF was significantly higher than in the right hemisphere(craniectomy site) of the sham operation group at 2 weeks, the expression showed a significant decrease at 1, 4, and 6 weeks (unpaired t-test, p<0.05). As compared with the left hemisphere (non-craniectomy site) of the sham operation group, the concentration of VEGF in the radiation group was significantly increased at 1, 2, 4, 6 and 8 weeks (p<0.05). (B) Although the concentration of VEGF at 8 weeks was higher than at 6 weeks in both groups, there was a significantly steep slope of expression in the radiation group between 6 and 8 weeks (unpaired t-test, p<0.05). a: right hemisphere (craniectomy site) in the radiation group; b: right hemisphere (craniectomy site) in the sham operation group; c: left hemisphere (non-craniectomy site) in the sham operation group.

^*p<0.05 by unpaired t-test within the radiation group; ^†p<0.05 by unpaired t-test compared between radiation and sham operation groups; ^‡p<0.05 by unpaired t-test compared between right hemisphere of the radiation group and left hemisphere of the sham operation group.