Table 3.
Inhibition of PGE2 (prostaglandin E2) formation in LPS-stimulated RAW264.7 cells by hydrolyzed-iridoids (H-iridoids)
| Test sample | 1 μM | 10 μM | 50 μM | 100 μM |
|---|---|---|---|---|
| H-aucubin | 92.3 ± 8.5 | 64.6 ± 6.4* | 41.3 ± 8.0* | 37.3 ± 4.0* |
| H-catalpol | 88.0 ± 4.0 | 87.0 ± 7.2 | 76.0 ± 8.8 | 75.3 ± 4.9* |
| H-loganin | 93.3 ± 6.1 | 88.0 ± 8.5 | 75.6 ± 9.2* | 55.3 ± 6.5* |
| H-gentiopicroside | 93.0 ± 6.5 | 95.6 ± 6.4 | 84.6 ± 4.7 | 86.0 ± 7.9 |
| H-swertiamarin | 96.3 ± 9.2 | 89.0 ± 5.2* | 84.6 ± 14.5 | 86.0 ± 7.9 |
| H-geniposide | 95.3 ± 5.0 | 89.3 ± 6.6 | 71.3 ± 9.0* | 64.0 ± 7.2* |
| H-geniposidic acid | 94.3 ± 6.6 | 93.6 ± 2.3 | 86.0 ± 7.9 | 78.0 ± 8.7 |
| genipin | 92.3 ± 6.8 | 90.0 ± 6.2 | 84.6 ± 7.3 | 91.3 ± 6.7 |
Values are presented as mean ± SD of the percentage of PGE2 formation of cultures treated with vehicle (DMSO) only.
*Statistically significant difference: P<0.05.