Table 4.
Inhibition of TNFα (tumor necrosis factor) production in LPS-stimulated RAW264.7 cells by hydrolyzed-iridoids (H-iridoids)
| Test sample | 1 μM | 10 μM | 50 μM | 100 μM |
|---|---|---|---|---|
| H-aucubin | 85.6 ± 11.0 | 63.6 ± 5.5* | 44.6 ± 10.5* | 24.0 ± 7.9* |
| H-catalpol | 95.6 ± 4.0 | 92.3 ± 8.0 | 69.3 ± 6.5* | 67.3 ± 8.9* |
| H-loganin | 96.6 ± 4.1 | 84.6 ± 5.1* | 71.0 ± 6.5* | 45.3 ± 3.5* |
| H-gentiopicroside | 89.6 ± 4.0 | 89.0 ± 6.0 | 82.6 ± 6.6 | 86.0 ± 6.5 |
| H-swertiamarin | 89.6 ± 4.0 | 93.6 ± 2.0 | 86.3 ± 4.7 | 89.3 ± 4.0 |
| H-geniposide | 93.3 ± 4.1 | 88.0 ± 8.5 | 71.0 ± 3.6* | 55.6 ± 4.0* |
| H-geniposidic acid | 100.0 ± 2.0 | 94.6± 12.5 | 84.0 ± 15.5 | 82.3 ± 7.3* |
| genipin | 102.3 ± 8.8 | 97.6 ± 7.3 | 94.0 ± 9.3 | 96.6 ± 8.1 |
Values are presented as mean ± SD of the percentage of TNFα production of cultures treated with vehicle (DMSO) only.
*Statistically significant difference: P < 0.05.