Table 4. Effect of light regimen on tumorigenesis in female rats.
Notes: TBR - tumor-bearing rats. Difference with the group LD is significant: a, р<0.05; b, р<0.01; c, р<0.001.
| Parameters | Light/dark regimen | ||||
| LD | NL | LL | DD | ||
| Number of rats | 40 | 48 | 54 | 61 | |
| Number of TBR (%) | 21 (52.5%) | 34 (70.8%)a | 24 (44.4%) | 15 (24.6%)c | |
| No. of tumors per TBR rat | 1.38 | 1.41 | 1.63 | 1.07 | |
| No. of mlgn. TBR rats (%) | 5 (12.5%) | 7 (14.6%) | 7 (13.0%) | 3 (4.9%) | |
| Number of tumors | 29 | 48 | 39 | 16 | |
| Time of the 1st tumor detection, days | 207 | 365 | 186 | 186 | |
| Mean life span of TBR, days | 769 ± 63.0 | 683 ± 22.9b | 665 ± 40.3 | 720 ± 64.3 | |
| Mean life span of malignant TBR, days | 1098 ± 21.8 | 688 ± 56.8c | 647 ± 79.8c | 809 ± 130.5a | |
| Localization and type of tumors | |||||
| Mammary gland: fibroma fibroadenoma adenocarcinoma | 4 | 9 | 1 | - | |
| 11 | 21 | 20 | 5 | ||
| - | - | 1 | - | ||
| No. of rats with benign mammary tumors | 14 | 27a | 18 | 5c | |
| Utery: polyp fibroma fibromyoma adenocarcinoma stromogenic sarcoma | 4 | 1 | 4 | 5 | |
| 1 | - | 1 | - | ||
| - | 2 | 1 | - | ||
| - | 3 | 1 | - | ||
| - | - | - | 1 | ||
| Oviduct: fibroma | - | 3 | - | - | |
| Adrenal gland: cortical adenoma carcinoma pheochromocytoma | 1 | 1 | 3 | 1 | |
| - | - | - | 1 | ||
| 2 | - | - | - | ||
| Ovary: fibroma luteoma hemangioma carcinoma | 1 | - | - | - | |
| - | 1 | - | - | ||
| - | - | - | 1 | ||
| - | 1 | - | - | ||
| Pituitary: adenoma | - | - | 1 | - | |
| Hematopoeitic tissue: leukemia/lymphoma | 3 | 3 | 4 | - | |
| Soft tissues: fibroma sarcoma | - | 1 | 1 | 1 | |
| 2 | 2 | 1 | - | ||
| Lung: adenocarcinoma | - | - | - | 1 | |
| Colon: adenocarcinoma | - | 1 | - | - | |
| Total: benign malignant | 24 | 39 | 32 | 13 | |
| 5 | 9 | 7 | 3 | ||