Table 6.
Histological changes observed in the liver, spleen, brain, lungs, heart, testes and stomach of rats treated with SYZ for 90 days.
| Organs | Histological changes | Grp I | Grp II | Grp IIIA | Grp IIIB |
| Liver | 1. Steatosis | − | ++ | + | |
| 2. Perivenular, periportal and sinusoidal inflammatory infiltrates |
− | + | ++ | ++ | |
| Spleen | Normal | − | − | − | − |
| Brain | 1. Oedema | + | + | +++ | +++ |
| 2. Congestion | − | − | +++ | +++ | |
| Lungs | Patchy atelectasis | + | + | + | + |
| Heart | Normal | − | − | − | − |
| Kidney | Tubular necrosis | − | − | ++ | ++ |
| Testes | Normal | − | − | − | − |
| StomachGastritis | − | + | ++ | ++ |
Key: − = no change; + = mild; ++ = moderate; +++ = severe
Grp I = control; Grp II = low dose; Grp IIIA = high dose; Grp IIIB = reversibility test