Table 1.
Effect of aqueous leaves extract of Ageratum conyzoides (A.C) on blood glucose levels after oral administration in normal fasted rats
| Group (n=5) |
Dose | Blood glucose levels at different hours after the treatment(mg/dl) | ||||
| 0h | 1.5h | 3h | 5h | 8h | ||
|
Control (distilled water) |
10ml/kg | 89.80±6.69 | 89±7.31 (−0.89%) |
80±6.78 (−10.91%) |
82±6.80 (−8.7%) |
79±5.87 (−12.03%) |
| A. C | 100mg/kg | 90.8±16.95 | 75±11.66 | 66.38±8.38 | 43.74±7.82* | 53.66±5.36 |
| (−17.4%) | (−26.9%) | (−51.83%) | (−40.90%) | |||
| A. C | 200mg/kg | 87.9±5.41 | 80.65±5.54 (−8.25%) |
72.26±3.96* (−17.79%) |
66.15±9.13* | (-24.74%) 58.90±5.20** (−33%) |
| A. C | 300mg/kg | 85±9.86 | 57.45±15.98 (−32.41%) |
73.50±9.73 (−13.53%) |
66.77±7.09 (−21.45%) |
54.10±2.30* (−36.35%) |
| Glibenclamide | 10mg/kg | 91.60±11.61 | 68±7.17* (−25.76%) |
46.2±9.78* (−49.56%) |
38.6±8.50** (−57.86%) |
33.60±5.86*** (−63.32%) |
The values in brackets represent the percentage reduction in blood glucose vs. initial value.
Values are means blood glucose levels ± S.E.M. of five animals.
*
p<0.01
**
p<0.001
***
p<0.0001 compared with the initial level of blood glucose of the rats (0h) in the respective group.