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CDH1 allele-specific quantification in CDH1-mutated and CDH1-negative probands. (A) ASE in CDH1 mutation carriers’ RNA and matched DNA. (B) Conventional boxplot (with whiskers) of allele expression ratio in cancer-free individuals (n = 21; IQR = 0.17; Q1 = 1.24; Q3 = 1.41), CDH1 mutation carriers (n = 5; IQR = 3.23; Q1 = 6.77; Q3 = 10) and CDH1 mutation-negative probands (n = 17; IQR = 7.02; Q1 = 2.96; Q3 = 9.98). P-values refer to Wilkoxon test (BC correction: ×3).
