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. 2009 Dec 3;19(5):737–751. doi: 10.1093/hmg/ddp538

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© The Author 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 10. — Proposed mechanism behind the formation of the KIR2DL3/2DP1 gene; deletion of ∼17 kb by homologous unequal intra-chromosomal recombination (Alu-mediated). A DNA break is introduced at the recombination hotspot site of an Alu repeat within a KIR gene. A second break occurs 17 kb away that contains sequence homologous to the first break site. The two homologous sequences serve as a substrate for double-strand break repair, which leads to deletion of the intervening sequences between the break sites.