Skip to main content
. 2009 Dec 3;19(5):737–751. doi: 10.1093/hmg/ddp538

Figure 7.

Figure 7.

The presumed order of genomic deletions in the formation of the j haplotype. First, a >50 kb deletion fused the KIR2DL1 and KIR2DS1 genes creating the KIR2DL1/S1 hybrid gene. Subsequently, a smaller ∼17 kb deletion fused the KIR2DL3 and KIR2DP1 genes to form the KIR2DL3/2DP1 gene. A representative KIR ‘B’ haplotype is shown below the deletion haplotypes as an example of one potential ancestral haplotype involved in the derivation of haplotype t. The represented haplotype was the most frequent observed in a panel of 85 Caucasoid individuals with a frequency of 0.124 (41). Apart from the ∼17 kb deletion and a single nucleotide, the j and t haplotype sequences are identical, raising the possibility of intra-chromosomal recombination in the formation of the j haplotype, and implicating the t haplotype as the single precursor of the j haplotype.