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. 2009 Dec 11;19(5):774–789. doi: 10.1093/hmg/ddp543

Figure 1.

Figure 1.

The csp1 and Prdm16Gt683Lex mutants exhibit CP. (A–G) Newborn csp1 and Prdm16Gt683Lex mutant pups die shortly after birth with a distended abdomen (A). Gross examination of mutant embryos identified the presence of a wide CP (open arrows) and pointed snout (white arrows) (B–D) accompanied by abnormal tongue position and morphology (E–G). Black arrows show the unaffected primary palate. (H–O) Histological analysis shows normal palate shelves at E13.5 that fail to elevate, remaining at the sides of the tongue at late E14.5 (I and M). Palate shelves remain in this position after normal palate fusion occurs by E15.5 (J and N) and do not undergo delayed elevation as evidenced by the failure of elevation at E19.5 (K and O) and postnatally (data not shown). T, tongue; Man, mandible; m, molar; i, incisor; MC, Meckel's cartilage.