Table 1.

Frequencies of chromosomal and telomeric abnormalities in bone marrow cells derived from wild-type and Fancc^−/− mice in C57BL/6 genetic background and G2 Tert^−/− Fancc^+/+ and Tert^−/− Fancc^−/− mice

Cell types	Aneuploidya	Chr. fragments and breaksb	SFEsb
Wild type	7.9 ± 1.8%	0%	0%
Fancc−/−	16 ± 4.3%	0%	0%
P-value	0.1842	NA	NA
G2 Tert−/−Fancc+/+	21.6 ± 1.7%	0.42 ± 0.21%	4.33 ± 1.22%
G2 Tert−/−Fancc−/−	7.2 ± 4.9%	0.63 ± 0.29%	0.73 ± 0.32%
P-value	0.07328	0.3948	0.0024

SFE, telomere signal-free end. The data were obtained from wild-type and Fancc^−/− mice (n = 6) as well as G2 Tert^−/− Fancc^+/+ and G2 Tert^−/− Fancc^−/− mice (n = 6), and more than 50 bone marrow cells from each mouse were scored. P-values were calculated by comparing wild-type with Fancc^−/− or G2 Tert^+/− Fancc^+/+ with Tert^+/− Fancc^−/− bone marrow cells.

^aPercentage of abnormal cells.

^bPercentage of abnormal events per chromosome.