Table 2. The 10 loci associated with colorectal cancer risk identified from GWA studies (Tenesa and Dunlop, 2009).

Gene/locus	Chromosome	SNP	Effect size (odds ratio)	Allele frequency	Population attributable risk (%)
—	8q24	rs6983267	1.21 (1.15–1.27)	0.51	9.7
GREM1	15q13	rs4779584	1.26 (1.19–1.34	0.18	4.5
SMAD7	18q21	rs4939827	1.18 (1.12–1.23	0.52	8.6
—	11q23	rs3802842	1.12 (1.07–1.17)	0.29	3.4
EIF3H	8q23	rs16892766	1.25 (1.19–1.32)	0.07	1.7
—	10p14	rs10795668	1.12 (1.10–1.16)	0.67	7.4
BMP4	14q21	rs4444235	1.11 (1.08–1.15)	0.46	4.8
CDH1	16q22	rs9929218	1.10 (1.06–1.12)	0.71	6.6
RHPN2	19q13	rs10411210	1.15 (1.10–1.20)	0.90	11.9
BMP2	20q12	rs961253	1.12 (1.08–1.16)	0.35	4.0

Abbreviation: GWA=genome-wide association.