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. 2009 Dec 15;102(2):351–360. doi: 10.1038/sj.bjc.6605486

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Copyright © 2010 Cancer Research UK

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Altered expression of Slug, Snail and E-cadherin in breast cancer cells by hypoxia. (A) Real-time PCR analysis of the expression of Snail in breast cancer cells with hypoxia. The increased expression of Snail with hypoxia was abrogated by either GSI treatment or DNMAML1. ^*P<0.05; ^**P<0.01. (B) Slug expression (both mRNA level and protein level) was increased in MDA-231 cells with hypoxia, which was abrogated by GSI treatment. ^*P<0.05. (C) Real-time PCR analysis of the expression of E-cadherin in breast cancer cells under 21% O₂ or 1% O₂ culture conditions with or without GSI treatment. ^*P<0.05. (D) Western blot analysis of E-cadherin expression in MCF7 cells with hypoxia. Dominant negative MAML1 abrogated the downregulation of E-cadherin during hypoxia. H, hypoxia; N, normoxia.