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. 2009 Dec 22;102(2):376–382. doi: 10.1038/sj.bjc.6605493

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Copyright © 2010 Cancer Research UK

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Different miRNA expression profiles of PTC variants, encapsulated benign and malignant lesions. Only miRNA 146b distinguishes every single PTC-TCV and PTC-CT from MNG and FA (A) whereas miRNAs 221 (D) and 222 (E) showed remarkable differences as well but failed to be a reliable diagnostic tool. PTC-FV and WDT-UMP revealed a broad variability in every type of miRNA analysed, covering the whole miRNA expression range that do not allow a clear distinction among tumour types. Mean values of miRNAs 146b and 21 differ significantly between FA and FTC in miRNA 21 (P=0.004; P<0.001).