Skip to main content
. 2010 Feb 5;6(2):e1000752. doi: 10.1371/journal.ppat.1000752

Figure 5. A model of the role of PKs in septin morphology and cell wall biogenesis.

Figure 5

Based on our observations, an intact septin ring is required for normal cell wall production and a normal cell wall is required for the formation of a septin ring. PK Cluster IV genes have known and predicted roles in septin morphology and signaling and may impact cell wall biogenesis indirectly via this role. We hypothesize PK Cluster I genes have direct roles in biogenesis of the cell wall, while PK Cluster III may indirectly effect cell wall biogenesis by regulating the flow of carbohydrates into cell wall biosynthesis pathways. We hypothesize that the genes in PK Cluster II are involved in cell wall stress response and the upregulation of cell wall integrity genes. PK Clusters I, III, and IV negatively regulate PK Cluster II, either directly or indirectly, based on the observation that cell wall integrity genes are upregulated in the absence of these PKs.