Table 1. Comparison of C. albicans, S. cerevisiae, and S. pombe mutant PK and PK-related cell wall stress sensitivity phenotypes.
| C. a. Gene name | Cell wall stress phenotype 1 | ||
| C. a. | S. c. 2 | S. p. 3 | |
| BCK1 | − | − | + |
| CBK1 | − | − | + |
| CKB1 | − | + | + |
| CKB2 | − | + | + |
| CLA4 | − | − | + |
| GIN4 | − | − | + |
| HSL1 | − | + | + |
| HST7 | − | + | + |
| IRE1 | − | − | + |
| KIN3 | − | − | + |
| KIS1 | − | + | + |
| MKC1 | − | − | − |
| MKK2 | − | − | + |
| MSS2 | − | − | N/A |
| PKC1 | − | − | + |
| PSK1 | − | − | + |
| PRK1 | − | + | + |
| RIO2 | − | + | + |
| SIP3 | − | + | + |
| SWE1 | − | + | − |
| TPK1 | − | + | + |
| VPS34 | − | − | + |
| YCK2 | − | + | + |
| YCK3 | − | + | + |
| CKA2 | + | − | ? |
| CPP1 | + | − | ? |
| PKH1 | + | + | − |
| RIM15 | + | + | − |
| SAT4 | + | + | − |
| KIN2 | + | + | − |
| YAK1 | + | + | − |
| PBS2 | + | + | − |
Genes listed are required for resistance to cell wall stress in at least one of the fungi represented: C. a. (C. albicans,) S. c. (S. cerevisiae), or S. p. (S. pombe). An entry of – means that a null mutation of this gene causes hypersensitivity to cell wall stress. An entry of + means that a null mutation of this gene does not alter sensitivity to cell wall stress. An entry of ? means the phenotype of the null mutation is unknown. Information for this table was gathered experimentally or from the Saccharomyces Genome Database (www.yeastgenome.org/), Biobase (portal.biobase-international.com/cgi-bin/portal/login.cgi), reference [18], and literature searches.
S. cerevisiae ortholog names do not always correspond to the C. albicans gene name. HST7 is ScSTE7, MKC1 is ScSLT2, and CPP1 is ScMSG5. PSK1 from C. albicans has two orthologs in S. cerevisiae, PSK1 and PSK2. The cell wall stress hypersensitivity is only observed in the double mutant. The observation that the Sckin3 and Scmss4 mutant strains are hypersensitive to cell wall stress is first reported in this work.
Many of the gene names are different between C. albicans and S. pombe. MKC1 is SpSPM1, SWE1 is SpWEE1, PKH1 is SpKSG1, RIM15 is SpCEK1, SAT4 is SpHAL4, KIN2 is SpKIN1, YAK1 is SpPOM1, PBS2 is SpWIS1, CKA2 is SpCKA1, and CPP1 is SpPMP1. Mutations in SpCKA1 and SpPMP1 have not been tested for sensitivity to cell wall stress and are marked ? for unknown. There is no obvious S. pombe ortholog to MSS2 and this cell is labeled N/A. The majority of S. pombe sensitivity assays were performed in SDS, which may impact more than just the cell wall.