Table 2. A comparison of C. albicans, S. cerevisiae, and S. pombe PK and PK-related mutant phenotypes.
| C. a. gene name | C. a. | S. c. 1 | S. p. 2 |
| Oxidative stress phenotype 3 | |||
| CHK1 | − | + | + |
| CKB1 | − | + | + |
| GIN4 | − | + | + |
| HOG1 | − | − | − |
| KIN4 | − | + | + |
| KIS1 | − | + | + |
| PBS2 | − | − | − |
| PRK1 | − | + | + |
| SLN1 | − | + | + |
| SSN3 | − | − | + |
| SSN8 | − | − | + |
| STE11 | − | + | + |
| VPS34 | − | + | + |
| MEC1 | + | − | ? |
| RCK2 | + | − | + |
| PKT2 | + | − | ? |
| Osmotic stress phenotype 3 | |||
| GIN4 | − | + | + |
| HOG1 | − | − | − |
| KIS1 | − | + | + |
| PBS2 | − | − | − |
| SOK1 | − | − | + |
| VPS34 | − | − | − |
| CKA2 | + | − | ? |
| CKB1 | + | − | ? |
| CKB2 | + | − | ? |
| HNT1 | + | − | ? |
| IES1 | + | − | N/A |
| KSP1 | + | − | ? |
| MKC1 | + | − | ? |
| SWE1 | + | − | + |
| SAT4 | + | + | − |
| KIN2 | + | ? | − |
| BCK1 | + | + | − |
| TPK2 | + | ? | − |
| CPP1 | + | ? | − |
| VPS15 | + | ? | − |
| Filamentation/morphology phenotype 3 | |||
| CBK1 | − | + | − |
| GIN4 | − | + | − |
| IRE1 | − | + | + |
| MSS2 | − | + | N/A |
| RIO2 | − | + | + |
| SOK1 | − | + | + |
| TPK2 | − | − | + |
| CLA4 | + | − | − |
| KIS1 | + | − | ? |
| HST7 | + | − | ? |
| STE11 | + | − | ? |
| CST20 | + | − | − |
| SWE1 | + | − | ? |
| CDC15 | + | ? | − |
| CKA2 | + | ? | − |
| KIN3 | + | ? | − |
| MEK1 | + | ? | − |
| PKC1 | + | ? | − |
| MEC1 | + | ? | − |
S. cerevisiae ortholog names do not always correspond to the C. albicans gene name. MKC1 is ScSLT2, CPP1 is ScMSG5, KIS1 is ScGAL83, HST7 is Sc STE7, and CST20 is ScSTE20. The observation that Scssn3 and Scssn8 mutants are hypersensitive to oxidative stress is first reported in this work. For the morphology defect portion of the table, observed morphological defects of S. cerevisiae fall into one of three categories: invasive growth defect, pseudohyphal growth defect, or both. The S. cerevisiae orthologs of TPK1, CLA4, KIS1, HST7, and CST20 are important for invasive growth. The S. cerevisiae orthologs of TPK2, HST7, STE11, CST20, and SWE1 are important for pseudohyphal growth.
Many of the gene names are different between C. albicans and S. pombe. HOG1 is SpSTY1, PBS2 is SpWIS1, MEC1 is SpRAD3, RCK2 is SpSRK1, PKT2 is most orthologous to SpSPCC70.05c, CKA2 is SpCKA1, HNT1 is SPCC1442.14c, MKC1 is SpSPM1, SWE1 is SpWEE1, SAT4 is SpHAL4, KIN2 is SpKIN1, BCK1 is SpMKH1, TPK2 is PKA1, CPP1 is SpPMP1, VPS15 is SpPPK19, CBK1 is SpORB6, GIN4 is SpCDR2, CLA4 is SpSHK2, KIS1 is SpSPCC1919.03c, HST7 is SpBYR1, STE11 is SpBYR2, CDC15 is SpCDC7, CKB1 is SpCKB2, KIN3 is SpFIN1, CST20 is SpPAK1, and PKC1 is SpPCK2. N/A refers to C. albicans genes that do not have known orthologs in S. pombe. Under the osmotic stress category, sensitivities of the Spkin2, Sptpk2 and Spvps15 mutants were noted using KCl instead of NaCl.
Genes listed are required for resistance to the indicated stress in at least one of the fungi represented: C. a. (C. albicans,) S. c. (S. cerevisiae), or S. p. (S. pombe). Oxidative stress generally refers to stress induced by H2O2, osmotic stress generally refers to stress induced by NaCl. Genes listed under filamentation/morphology phenotype are required for appropriate morphology or are required for changes in morphology. An entry of – means that a null mutation of this gene causes hypersensitivity to cell wall stress or defective morphology. An entry of + means that a null mutation of this gene does not alter sensitivity to cell wall stress or have normal morphology. An entry of ? means the phenotype of the null mutation is unknown. Information for this table was gathered experimentally or from the Saccharomyces Genome Database (www.yeastgenome.org/), Biobase (portal.biobase-international.com/cgi-bin/portal/login.cgi), reference [18], and literature searches.