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. 2010 Feb 5;6(2):e1000756. doi: 10.1371/journal.ppat.1000756

Figure 10. Anti-inflammatory type I IFN inhibits virus-induced ALI in aged SARS-CoV-infected macaques.

Figure 10

(A) Gross pathology scores of lungs from macaques were determined during necropsy and averaged (±s.e.m.). (B) Average fold change (±s.e.m.) in SARS-CoV mRNA levels in the lungs of pegylated IFN-α-treated (n = 3) and untreated aged (n = 6) macaques compared to aged PBS-infected (n = 4) animals as determined by real-time RT-PCR. (C) Number of differentially expressed gene transcripts compared to aged PBS-infected animals (≥2-fold change). (D) Quantitative RT-PCR for IL-8 was performed on two-three separate lung samples per animal with substantial virus replication. The data presented are error-weighted (±s.e.m.) averages of the fold-change as compared to PBS-infected controls for aged animals (n = 6) and aged animals treated with IFN-α (n = 3).