Figure 3.

Effect of cobinamide and hydroxocobalamin on tissue oxy- and deoxyhemoglobin concentrations in all cyanide-poisoned rabbits. The mean and standard error of percent change in (a) oxyhemoglobin (OHb) and (b) deoxyhemoglobin (RHb) concentrations from baseline are shown during cyanide infusion and treatment for control animals and for hydroxocobalamin-treated (IV OHCob) or cobinamide-treated (IV Cob) animals. (a) Tissue deoxyhemoglobin concentrations rise rapidly from their levels at the end of the cyanide infusion in cobinamide-treated animals compared to controls and hydroxocobalamin animal groups. (b) Tissue oxyhemoglobin concentrations fall significantly faster from their peak value at the end of cyanide infusion following treatment with cobinamide compared to hydroxocobalamin or controls.