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. 2010 Feb 8;5(2):e9103. doi: 10.1371/journal.pone.0009103

Figure 3. Peptides from BH4 domains of hBCL2 and hBCL2A1 protect skeletal muscle From I/R injury.

Figure 3

Mice were pretreated with (A) synthetic BH4-BCL2 peptide (10 µg/mouse), (B) BH4-BCL2A1 peptide (10 µg/mouse), (C) BH3-Bak peptide (10 µg/mouse), or control scrambled peptide (10 µg/mouse) given ip on the day prior to hind limb I/R induced by tourniquet for 90 minutes of ischemia, followed by 3 hours of reperfusion. Plasma CK levels were significantly less in mice pretreated with hBCL2-BH4 or hBCL2A1-BH4 compared to mice pretreated with a scrambled peptide (*p<0.05).