Figure 1.

Leukemia-originating stem cell model. Functional studies in acute myeloid and chronic leukemias have led to the identification and characterization of the leukemia-originating stem cells (LSCs), which share features with normal hematopoietic stem cells (HSCs). LSCs derive either from HSCs, multipotent progenitors (MPPs), committed progenitor cells or even more differentiated cells that accumulate mutations that reprogram the necessary stem-cell features to generate and regenerate tumors.