Table 2.
MCP-1 production in recombinant CRP or LPS-stimulated whole blood before and after administration of pravastatin
| MCP-1 concentration (pg/ml) |
|||
|---|---|---|---|
| Incubation time | Before pravastatin | After pravastatin | P-values |
| Unstimulated (Saline) | |||
| 6 hours | 105.2 ± 20.9 | 111.4 ± 21.3 | 0.53 |
| 10 hours | 157.1 ± 35.0 | 150.6 ± 31.2 | 0.65 |
| 24 hours | 303.6 ± 108.1 | 407.4 ± 450.2 | 0.43 |
| 5 µg/mL CRP | |||
| 6 hours | 442.3 ± 85.6 | 417.4 ± 72.7 | 0.69 |
| 10 hours | 1,291.0 ± 229.4 | 1,458.9 ± 227.6 | 0.31 |
| 24 hours | 3,157.5 ± 632.3 | 3,083.0 ± 629.1 | 0.65 |
| 1 µg/mL LPS | |||
| 6 hours | 530.3 ± 101.6 | 502.4 ± 97.0 | 0.87 |
| 10 hours | 759.0 ± 441.6 | 750.7 ± 471.1 | 0.73 |
| 24 hours | 1,139.0 ± 879.4 | 899.4 ± 884.1 | 0.10 |
Values are mean SEM from 15 experiments performed in duplicates.
The net production of MCP-1 was calculated by subtracting the concentration without stimulus from those induced by LPS or recombinant CRP.
Wilcoxon signed rank test was applied for statistical analysis.