Table 1.

Comparison between, the mucosal to serosal (M to S) and the serosal to mucosal (S to M) flux of gliclazide, at steady state (Jss), after treatment with probiotics, in tissues from healthy and diabetic rats. Tissues resistance through the course of the experiments, and the current change after glucose challenge, are shown. Data are mean ± SD

			Resistance (Ω.cm2) N = 32		Δ Short Circuit current (Isc) after glucose challenge (µA/cm2) N = 32
Groups	Jss (M to S)(µg/min/cm2) N = 16	Jss (S to M)(µg/min/cm2) N = 16	M to S N = 16	S to M N = 16	M to S N = 16	S to M N = 16
Healthy (control)	1.18 ± 0.27	0.62 ± 0.14	41.03 ± 8.4	46.17 ± 10.6	30.36 ± 7.91†	33.14 ± 9.7†
Healthy-probiotic	0.26 ± 0.05*	1.38 ± 0.29*	55.03 ± 9.4	41.17 ± 8.6	35.9 ± 6.5†	29.21 ± 5.8†
Diabetic (control)	0.34 ± 0.09	0.35 ± 0.10	44.25 ± 9.97	45.39 ± 8.4	41.08 ± 6.23†	38.47 ± 8.14†
Diabetic-probiotic	1.26 ± 0.26*	0.66 ± 0.19*	50.25 ± 11.7	46.22 ± 10.6	37.4 ± 4.8†	40.36 ± 7.66†

^*P < 0.01 gliclazide flux at steady state compared with the corresponding control.

^†P < 0.01 Isc after glucose challenge compared with zero difference.