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The 5′-UTR of Nrf2 contains an inhibitory element. (A) The mFold algorithm predicted the existence of a hairpin structure (boxed) upstream of the RBS1. The positions of RBS1 and RBS2 are indicated by green and yellow fonts on black box, respectively. (B) The IRESNrf2 secondary structure deduced by NMIA probing. The arrows indicate NMIA reactive sites. The RBS1 and RBS2 motifs are highlighted (C) Deletion of the IE segment (ΔN1) robustly enhanced Nrf2 IRES activity.
