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. 2009 Nov 24;38(3):942–957. doi: 10.1093/nar/gkp1059

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Summary of this study. Effects of the trmB gene disruption are depicted. The lack of the m⁷G46 modification causes hypo-modification of other nucleotides in class I tRNA. The melting temperature of the tRNA decreases, and tRNA^Phe and tRNA^Ile are degraded. The degradation of tRNA depresses protein synthesis and the ΔtrmB strain exhibits a severe growth defect at high temperatures. These experimental results suggest the existence of a tRNA modification network, in which the m⁷G46 modification catalyzed by TrmB may act as one of the key factors.