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. 2009 Nov 24;38(3):797–809. doi: 10.1093/nar/gkp1072

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Effect of UVB on XPC expression. Keratinocytes were harvested at the indicated time points after irradiation. (A) Total protein extracts were assessed for the presence of the XPC and HIF-1α protein by western blotting. β-actin was used as a loading control. Arrowheads indicate the two HIF-1α forms [see also ref. (14)]. (B) The band intensities of XPC proteins were quantified densitometrically. (C) The relative level of XPC mRNA was determined by qRT-PCR. The results are expressed as the mean ± SD of three independent experiments. –, no UVB exposure; Ker/NT, non-transduced keratinocytes; Ker/shHIF-1α, keratinocytes transduced with shHIF-1α; Ker + DMOG, keratinocytes treated with dimethyloxaloylglycine. *P < 0.05 for cells at the indicated time point versus non-transduced cells prior to irradiation.