Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Step of biosynthetic pathway, site of action, and blocking agents.
| Step of biosynthetic pathway | Site of action | Blocking agent |
|---|---|---|
| Flap (five-lipoxygenase activating protein) | Cell membrane | Not developed commercially |
| 5-LO (5-lipoxygenase) | Citosol | Zileuton |
| Citosol | Via-2291 | |
| Translocation of 5-lipoxygenase | Binding sites | DG-031 (BAY × 1005) |
| Cell membrane | ||
| CysLT1 receptor | Target cells | Montelukast |
| Zafirlukast | ||
| Pranlukast |
