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. 2010 Mar;51(3):535–543. doi: 10.1194/jlr.M000786

TABLE 2.

[3H]AA half-lives in rat brain phospholipids

n-3 PUFA Diet Group Brain Lipid Slope, Days SE, Days P Value T1/2 (days) Jout (µmol/brain/day) Loss/Brain/Day (%)
Adequate
Total PL −0.006830 0.0006142 <0.0001 44 0.248 1.6
ChoGpl −0.01110 0.0007045 <0.0001 27 0.103 2.6
EtnGpl −0.006694 0.0006154 <0.0001 45 0.149 1.5
PtdIns −0.01137 0.0008117 <0.0001 26 0.080 2.6
PtdSer −0.005847 0.0007621 <0.0001 51 0.014 1.4
Deprived
Total PL −0.006581 0.0005942 <0.0001 46 0.281 1.5
ChoGpl −0.01067 0.0006158 <0.0001 28 0.123 2.4
EtnGpl −0.005873 0.0006609 <0.0001 51 0.149 1.4
PtdIns −0.01071 0.0007731 <0.0001 28 0.088 2.5
PtdSer −0.005276 0.0007224 <0.0001 57 0.015 1.0

Slopes for decline of [3H] AA radioactivity in brain phospholipids and corresponding calculated half-lives, equation 3, (T1/2) = log10 (2)/slope of regression line and rates of AA loss; equation 4, Jout (µmol/brain/day) = ln(2)CAA/T1/2. p-values designate significance of difference of slope from 0. ChoGpl and PtdIns were significantly different compared with EtnGpl and PtdSer within the same dietary group; P < 0.05. Mean ± SE brain weight; 2.02 ± 0.34 and 2.10 ± 0.52 g, n-3 PUFA adequate and deprived groups, respectively. See Table 1 for abbreviations.