TABLE 2.
Liver weight and liver lipid composition in mice on the C57BL/6 genetic background with different hepatic SR-BI expression
| Increased Expression |
Decreased Expression |
|||
|---|---|---|---|---|
| AdNull | AdSR-BI | C57BL/6 | SR-BI ko | |
| Liver weight (% of bw) | 4.48 ± 0.21 | 6.27 ± 0.13§ | 4.42 ± 0.19 | 4.15 ± 0.38 |
| Total cholesterol (µmol/g) | 6.26 ± 0.18 | 8.07 ± 0.61§ | 5.90 ± 0.18 | 6.49 ± 0.19§ |
| Free cholesterol (µmol/g) | 4.48 ± 0.33 | 6.02 ± 0.56§ | 4.26 ± 0.10 | 4.65 ± 0.14§ |
| Phospholipids (µmol/g) | 34.2 ± 2.4 | 35.4 ± 5.3 | 32.2 ± 1.2 | 33.7 ± 0.8 |
| Triglycerides (µmol/g) | 12.0 ± 8.0 | 27.2 ± 3.8§ | 8.3 ± 1.5 | 9.2 ± 2.1 |
Values are means ± SEM.
In the experiments involving the use of recombinant adenovirus livers were analyzed on day 7 following virus administration. Significantly different from the respective control group: § at least P < 0.05.