Skip to main content
. 2009 Dec 23;24(2):359–369. doi: 10.1210/me.2009-0346

Figure 2.

Figure 2

Dioxin responsiveness is a characteristic of both ER-negative and ER-positive breast cancer cells. A, CYP1A1, CXCR4, and MMP-9 in SKBR3 or MDA MB-231 ER-negative breast cancer cells after 24-h exposure to 10 nm TCDD. Cells were harvested for total RNA, which was used for qPCR. Tabular data are represented as fold induction over vehicle (Veh) (set at 1). B and C, Fold induction of CYP1A1, CXCR4, and MMP-9 in MCF-7 or ZR-75-1 ER-positive breast cancer cells. For panels A–C, data represent the average of triplicate amplification reactions for each condition in a representative experiment; n = 3 independent assays. *, P < 0.05 for comparison between Veh and TCDD. +, P < 0.05 for comparison between Veh and E2. a, P < 0.05 for comparison between E2 and E2 + TCDD.