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. 2009 Dec 11;24(2):335–345. doi: 10.1210/me.2008-0081

Figure 3.

Figure 3

The sequence region of the PR NTD (N) between aa 323 and aa 475 is necessary, but not sufficient, for the partial agonist activity of RU486. A, Schematic illustration of PR-B constructs including WT-PR-B, truncation 350-DhLBD, and 323-427-DhLBD constructs. B, COS-1 cells were transfected with PRE2-TATA-Luc (200 ng) together with single concentrations of WT-PR-B and PR constructs in the presence or absence of pCR3.1-JDP-2 (100 ng). Cells were treated for the final 24 h with vehicle or 10 nm RU486, as indicated. Fold enhancement by JDP-2 was calculated as in Fig. 1. Values are averages ± sem of at least three independent experiments. WT, Wild type; DhLBD, DBD-hLBD.