Table 3.

All mir-22 predicted target genes that were overexpressed in clear cell ovarian cancer

Gene	Description	Microarray fold change (clear cell vs. NOSE)	Microarray fold change (mir-22 overexpression)	Algorithm
EDC3	Enhancer of mRNA decapping 3 homolog (S. cerevisiae)	+2.03	−2.22	T, P
FRAT2	Frequently rearranged in advanced T-cell lymphomas 2	+3.23	−1.70	T
EVI1	Ecotropic viral integration site 1	+22.41	−1.59	T
ARID3B	AT-rich interactive domain 3B (BRIGHT-like)	+4.17	−1.58	T, P
CHD7	Chromodomain helicase DNA-binding protein 7	+2.35	−1.58	T, P
CLIP2	CAP-GLY domain containing linker protein 2	+2.64	−1.48	P
AGBL5	ATP/GTP binding protein-like 5	+2.09	−1.44	T, P
FBX046	F-box protein 46	+2.23	−1.43	T
ZCCHC14	Zinc finger, CCHC domain containing 14	+2.14	−1.42	T
PDSS1	Prenyl (decaprenyl) diphosphate synthase, subunit 1	+2.05	−1.40	T
FAM125B	Family with sequence similarity 125, member B	+2.55	−1.37	T
BIN1	Bridging integrator 1	+4.75	−1.26	P
CYTH3	Cytohesin 3	+2.12	−1.26	T, P
MTHFD2	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	+4.34	−1.25	T, P
POGK	Pogo-transposable element with KRAB domain	+2.41	−1.19	T, P
CCDC47	Coiled-coil domain containing 47	+2.07	−1.18	T, P
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	+2.09	−1.17	T
ARRB1	Arrestin, β 1	+2.25	−1.09	T
RGS14	Regulator of G protein signaling 14	+2.09	−1.09	T
ACVR1B	Activin A receptor, type IB	+4.37	−1.07	T
ZNF618	Zinc finger protein 618	+2.59	−1.06	T
PPP1R9A	Protein phosphatase 1, regulatory (inhibitor) subunit 9A	+2.40	−1.05	T
MPHOSPH9	M-phase phosphoprotein 9	+2.35	1.00	P
ANKRD57	Ankyrin repeat domain 57	+3.21	+1.02	P
ERBB3	v-erb-b2 Erythroblastic leukemia viral oncogene homolog 3 (avian)	+13.27	+1.08	T, P
PLAGL2	Pleiomorphic adenoma gene-like 2	+3.82	+1.11	T, P
IGF2BP3	IGF 2 mRNA-binding protein 3	+8.48	+1.19	P

Of 27 genes, 22 were down-regulated after mir-22 overexpression. Prediction algorithms: T, TargetScan; P, PicTar; M, miRanda.