Table 4.
Top 25 mir-182 predicted target genes that were underexpressed in clear cell ovarian cancer and up-regulated after mir-182 knockdown
| Gene | Description | Microarray fold change (clear cell vs. NOSE) | Microarray fold change (mir-182 knockdown) | Algorithm |
|---|---|---|---|---|
| CAMSAP1L1 | Calmodulin regulated spectrin-associated protein 1-like 1 | −2.19 | +1.15 | T, P, M |
| SNAP23 | Synaptosomal-associated protein, 23 kDa | −4.36 | +1.14 | T, P, M |
| SP3 | Sp3 transcription factor | −2.07 | +1.14 | T, P, M |
| CD164 | CD164 molecule, sialomucin | −3.03 | +1.13 | T |
| ATXN1 | Ataxin 1 | −4.98 | +1.12 | T, P, M |
| PLCG1 | Phospholipase C, γ 1 | −2.44 | +1.12 | T, P |
| NAMPT | Nicotinamide phosphoribosyltransferase | −5.11 | +1.11 | T, P, M |
| BNC2 | Basonuclin 2 | −3.22 | +1.11 | T, P, M |
| EIF5A2 | Eukaryotic translation initiation factor 5A2 | −2.84 | +1.11 | T, P, M |
| ZHX1 | Zinc fingers and homeoboxes 1 | −2.16 | +1.11 | T, P |
| EFNB2 | Ephrin-B2 | −4.16 | +1.10 | T, P, M |
| ACVR1 | Activin A receptor, type I | −2.32 | +1.10 | T, P, M |
| EVI5 | Ecotropic viral integration site 5 | −2.21 | +1.10 | T, P, M |
| PLOD2 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | −26.14 | +1.09 | T, P |
| MBNL2 | Muscleblind-like 2 (Drosophila) | −4.41 | +1.09 | T, P, M |
| SEPT7 | Septin 7 | −3.28 | +1.09 | T, P |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae) | −2.94 | +1.09 | T, P, M |
| AHR | Aryl hydrocarbon receptor | −2.54 | +1.09 | T |
| SMAD7 | SMAD family member 7 | −2.34 | +1.09 | T, P |
| YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, γ polypeptide | −3.59 | +1.08 | T, P, M |
| SBDS | Shwachman-Bodian-Diamond syndrome | −3.20 | +1.08 | T |
| ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2 | −2.69 | +1.08 | T |
| ADAM10 | ADAM metallopeptidase domain 10 | −2.31 | +1.08 | T, P, M |
| PDGFRA | Platelet-derived growth factor receptor, α polypeptide | −13.38 | +1.07 | T, P, M |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | −2.14 | +1.07 | T, P, M |
The table lists only those targets that were at least predicted by TargetScan. Prediction algorithms: T, TargetScan; P, PicTar; M, miRanda.