Figure 5.
ERαLysM−/− mice lose bone mass after OVX. Female mice (22 wk of age) were sham operated or ovariectomized and killed 6 wk later. A, Number of TRAP-positive cells generated from bone marrow cells cultured with M-CSF and RANKL for 5 d. B and C, Histomorphometric analysis of longitudinal undecalcified sections of L1–L3 vertebrae from 28-wk-old female mice (n = 8 mice per group). D, First and third panels depict BMD determinations by DEXA before mice were killed. Second and fourth panels depict the percent change from the initial BMD, which was determined 1 d before surgery (n = 10–13 mice per group). BA/TA, Bone area per tissue area; Tb, trabecular; ns, not significant. *, P < 0.05.