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. 2009 Dec 23;151(2):793–801. doi: 10.1210/en.2009-0976

Figure 3.

Figure 3

Cre recombinase is biologically active in transgenic TRH-Cre mice. A, Representation of the TRH BAC in TRH-Cre mice. The Cre is inserted into the second exon of TRH. B, To show that the Cre recombinase in TRH-Cre mice is biologically active, TRH-Cre mice were crossed with Rosa-26 GFP mice. IHC staining was performed for GFP on TRH-Cre mice from the Founder 40 line (F40: TRH-Cre) and TRH-Cre x Rosa-26 GFP mice from both the Founder 40 and founder 5 lines (F40: TRH-Cre x R26-GFP and F5: TRH-Cre x R26-GFP). Magnification, ×10; scale bars per column, 100 μm.